Hypervaccination seems to have no impact on the immune system finds a new study published in The Lancet Infectious Diseases journal. The researchers have examined a man in Germany who claims to have received 217 vaccinations against COVID-19 and found that his immune system was fully functional.
Some scientists thought that immune cells would become less effective after becoming used to the antigens.However, the case study published in The Lancet Infectious Diseases journal found that the immune system of the person is fully functional.
Of the 217 vaccinations the man has received, which he says are for private reasons, there is official confirmation for 134 of them.

What is hypervaccination?

Hypervaccination refers to the excessive administration of vaccines, posing potential risks to individuals and public health. While vaccines are crucial for preventing diseases, overvaccination may lead to adverse reactions, including allergic reactions, autoimmune disorders, and neurological complications. Moreover, excessive vaccination can strain healthcare resources and undermine confidence in vaccination programs. Careful assessment of individual health risks and benefits is essential to avoid unnecessary vaccinations. Public health efforts should prioritize evidence-based vaccination schedules and communication to ensure optimal protection against diseases while minimizing the risk of adverse events associated with hypervaccination.

Study negates the prior understanding that vaccination weakens immunity

“We learned about his case via newspaper articles,” said Kilian Schober from Friedrich–Alexander University Erlangen–Nurnberg (FAU) in Germany.
“We then contacted him and invited him to undergo various tests in Erlangen (a city in Germany). He was very interested in doing so,” he said.
The researchers wanted to analyse what happens if the body’s immune system is exposed extremely often to a specific antigen. “That may be the case in a chronic infection such as HIV or hepatitis B, that has regular flare-ups,” explained Schober.
“There is an indication that certain types of immune cells, known as T-cells, then become fatigued, leading to them releasing fewer pro-inflammatory messenger substances,” he added.
This and other effects triggered by the cells becoming used to the antigens can weaken the immune system, which is then no longer able to combat the pathogen so effectively.
However, the study does not deliver any indication that this is the case, the researchers said.

Outcomes

“We were also able to take blood samples ourselves when the man received a further vaccination during the study at his own insistence. We were able to use these samples to determine exactly how the immune system reacts to the vaccination,” Schober said.
The results showed that the individual has large numbers of T-effector cells against SARS-CoV-2. These act as the body’s own soldiers that fight against the virus, the researchers said.
The person even had more of these compared to the control group of people who had received three vaccinations, they said.
The researchers did not perceive any fatigue in these effector cells. They were similarly effective as those in the control group who had received the normal number of vaccinations.
They also explored memory T cells — cells at a preliminary stage, similar to stem cells, that can replenish numbers of suitable effector cells.
“The number of memory cells was just as high in our test case as in the control group,” explained Katharina Kocher, one of the leading authors of the study.
“Overall, we did not find any indication for a weaker immune response, rather the contrary,” Kocher added.
(With inputs from PTI)





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